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Retatrutide (LY3437943) is a synthetic 39-amino-acid, C20 fatty-diacid-acylated peptide engineered as a simultaneous agonist at the GLP-1, GIP, and glucagon receptors. It has been investigated in preclinical and in-vitro model systems as a reference tool compound for studying coordinated triple incretin/glucagon receptor co-activation. Retatrutide is an investigational compound and is not an approved drug.